Invitrogen™ GluR6 Recombinant Rabbit Monoclonal Antibody (4B4L9)

Catalog No.	Quantity
PIMA538204	100 μL

Catalog No. PIMA538204 Supplier Invitrogen™ Supplier No. MA538204

Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: Mouse brain, 293T Immunogen sequence: MGAEELAFRF AVNTINRNRT LLPNTTLTYD TQKINLYDSF EASKKACDQL SLGVAAIFGP SHSSSANAVQ SICNALGVPH IQTRWKHQVS DNKDSFYVSL Y.

Glutamate receptors are the primary excitatory neurotransmitter receptors in the mammalian brain and are activated during various normal neurophysiological processes. The kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels, includes this gene product. The subunit encoded by this gene is edited at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Furthermore, different isoforms of this gene have been described due to alternatively spliced transcript variants. Mutations in this gene have been linked to autosomal recessive cognitive disability. GRIK2-associated diseases include Neurodevelopmental Disorder with Impaired Language and Ataxia and with or without Seizures and Intellectual Developmental Disorder, Autosomal Recessive 6.

Specifications

• Antigen: GluR6
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Recombinant Monoclonal
• Clone: 4B4L9
• Concentration: 0.27 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: GRIK2
• Gene Accession No.: P39087, P42260, Q13002
• Gene Alias: AW124492; bA487F5.1; EAA4; Excitatory amino acid receptor 4; GLR 6; GLR6; GluK2; GLUK6; GLUR 6; gluR beta-2; Glur6; Glur-6; Glurbeta2; glutamate ionotropic receptor kainate type subunit 2; glutamate receptor; glutamate receptor 6; Glutamate receptor beta-2; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; glutamate receptor ionotropic, kainate 2; glutamate receptor, ionotropic kainate 2; glutamate receptor, ionotropic, kainate 2; glutamate receptor, ionotropic, kainate 2 (beta 2); glutamate receptor, ionotropic, kainate 5; GRIK 2; Grik2; GRIK2 protein; grik2alpha; grik2l; MRT6
• Gene Symbols: GRIK2
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human GRIK2 (Q13002).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 14806, 2898, 54257
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG