Invitrogen™ GLUT1 Recombinant Rabbit Monoclonal Antibody (10O1I5)

Catalog No.	Quantity
PIMA537843	100 μL

Catalog No. PIMA537843 Supplier Invitrogen™ Supplier No. MA537843

Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: SH-SY5Y, K-562, Mouse brain Immunogen sequence: ELFSQGPRPA AIAVAGFSNW TSNFIVGMCF QYVEQLCGPY VFIIFTVLLV LFFIFTYFKV PETKGRTFDE IASGFRQGGA SQSDKTPEEL FHPLGADSQV.

Glucose transporter 1 (GLUT1), encoded by the SLC2A1 gene, is a facilitative glucose transporter that plays a pivotal role in the uptake of glucose across cell membranes, particularly in tissues with high-energy demands such as the brain, erythrocytes, and endothelial cells of the blood-brain barrier. GLUT1 is ubiquitously expressed and functions through a passive diffusion mechanism, allowing glucose to move down its concentration gradient. Its involvement in maintaining glucose homeostasis is crucial for cellular metabolism and energy production. Mutations in SLC2A1 can lead to GLUT1 deficiency syndrome, characterized by seizures, developmental delay, and movement disorders due to impaired glucose transport into the brain. GLUT1 also plays a significant role in cancer biology, where its overexpression is commonly observed in various tumors, facilitating the enhanced glucose uptake required for rapid tumor cell proliferation. This characteristic makes GLUT1 a potential target for cancer diagnostics and therapeutics. Additionally, GLUT1's regulation is influenced by factors such as hypoxia, insulin, and cellular stress, highlighting its adaptive role in different physiological and pathological states.

Specifications

• Antigen: GLUT1
• Applications: ELISA, Immunohistochemistry (Paraffin), Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: 10O1I5
• Concentration: 0.25 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: SLC2A1
• Gene Accession No.: P11166, P17809
• Gene Alias: choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity); CSE; DYT17; DYT18; DYT9; EIG12; glucose transporter glut1; glucose transporter type 1, erythrocyte/brain; glucose transporter type I; GLUT; Glut1; Glut-1; GLUT1DS; GLUTB; GT1; GTG1; Gtg3; HepG2 glucose transporter; HTLVR; human T-cell leukemia virus (I and II) receptor; MGC141895; MGC141896; PED; RATGTG1; receptor for HTLV-1 and HTLV-2; SDCHCN; Slc2a1; solute carrier family 2 (facilitated glucose transporter), member 1; Solute carrier family 2 a 1 (facilitated glucose transporter) brain; solute carrier family 2 member 1; solute carrier family 2, facilitated glucose transporter member 1; solute carrier family 2, member 1
• Gene Symbols: SLC2A1
• Host Species: Rabbit
• Immunogen: Synthetic peptide.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 20525, 6513
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov