Invitrogen™ Glutaminase C (GAC) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA540134

Catalog No. PA540134

Description

This antibody specifically recognizes GAC but not the KGA isoform. Predicted reactivity: Bovine (100%). Recommended positive controls: MDA-MB-231 and cholangiocarcinoma tissue. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Sahai (1983) demonstrated phosphate-activated glutaminase (EC 3.5.1.2) in human platelets. It is the major enzyme yielding glutamate from glutamine. Significance of the enzyme derives from its possible implication in behavior disturbances in which glutamate acts as a neurotransmitter(Prusiner, 1981). High heritability of platelet glutaminase was indicated by studies of Sahai and Vogel (1983) who found an intraclass correlation coefficient of 0.96 for monozygotic twins and 0.53 for dizygotic twins.

Specifications

• Antigen: Glutaminase C (GAC)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GLS
• Gene Alias: 6330442B14; AAD20; AI314027; B230365M23Rik; GAC; GAM; GLS; Gls1; Glut; glutaminase; glutaminase C; glutaminase kidney isoform, mitochondrial; Glutaminase kidney isoform, mitochondrial 65 kDa chain; Glutaminase kidney isoform, mitochondrial 68 kDa chain; glutaminase, phosphate-activated; KGA; K-glutaminase; KIAA0838; L-glutamine amidohydrolase; RATGLUT
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14660, 2744
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: D3Z7P3, O94925
• Gene Symbols: GLS
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human Glutaminase C.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG