Invitrogen™ Glutamine Synthetase Monoclonal Antibody (CL3004)

Catalog No.	Quantity
PIMA535006	100 μL

Catalog No. PIMA535006 Supplier Invitrogen™ Supplier No. MA535006

Description

Mouse Monoclonal Antibody

Immunogen sequence: LQSEGSNSDM YLVPAAMFRD PFRKDPNKLV LCEVFKYNRR PAETNLRHTC KRIMDMVSNQ HPWFGMEQEY TLMGTDGHPF GWPSNGFPGP QGPYYCGVGA DRAYGRDIVE AHYRACLYAG VKIAGTNAEV MPAQWEFQIG P Highest antigen sequence indentity to the following orthologs: Rat - 92%, Mouse - 95%.

Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. It also has an important role in controlling metabolic regulations of neurotransmitter glutamate. Because of the multiple functions and importance of GS in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of GS is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation.

Specifications

• Antigen: Glutamine Synthetase
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: CL3004
• Concentration: 1.0 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: GLUL
• Gene Accession No.: P09606, P15104, P15105
• Gene Alias: cell proliferation-inducing protein 59; GLNA; GLNS; Glul; GLUL protein; Glutamate ammonia ligase; glutamate decarboxylase; glutamate-ammonia ligase; glutamate--ammonia ligase; glutamate-ammonia ligase (glutamine synthase); glutamate-ammonia ligase (glutamine synthetase); glutamine synthase; glutamine synthetase; Glutamine synthetase (glutamate-ammonia ligase); glutamine synthetase 1; glutamine synthetase I; GS; Palmitoyltransferase GLUL; PIG43; PIG59; Proliferation inducing protein 43; proliferation-inducing protein 43
• Gene Symbols: GLUL
• Host Species: Mouse
• Immunogen: Recombinant protein fragment of Human GLUL (Product #RP-88685).
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 14645, 24957, 2752
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1