Invitrogen™ Glutamine Synthetase Polyclonal Antibody

Catalog No.	Quantity
PIPA582305	100 μL

Catalog No. PIPA582305 Supplier Invitrogen™ Supplier No. PA582305

Description

Rabbit Polyclonal Antibody

Immunogen sequence: RVCEDFGVIA TFDPKPIPGN WNGAGCHTNF STKAMREENG LKYIEEAIEK LSKRHQYHIR AYDPKGGLDN ARRLTGFHET SNINDFSAGV ANRSASIRIP RTVGQEKKGY FEDRRPSANC DPFSVTEALI RTCLLNETG Highest antigen sequence indentity to the following orthologs: Rat - 94%, Mouse - 95%.

Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. It also has an important role in controlling metabolic regulations of neurotransmitter glutamate. Because of the multiple functions and importance of GS in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of GS is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation.

Specifications

• Antigen: Glutamine Synthetase
• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.10 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: GLUL
• Gene Accession No.: P15104
• Gene Alias: cell proliferation-inducing protein 59; GLNA; GLNS; Glul; GLUL protein; Glutamate ammonia ligase; glutamate decarboxylase; glutamate-ammonia ligase; glutamate--ammonia ligase; glutamate-ammonia ligase (glutamine synthase); glutamate-ammonia ligase (glutamine synthetase); glutamine synthase; glutamine synthetase; Glutamine synthetase (glutamate-ammonia ligase); glutamine synthetase 1; glutamine synthetase I; GS; Palmitoyltransferase GLUL; PIG43; PIG59; Proliferation inducing protein 43; proliferation-inducing protein 43
• Gene Symbols: GLUL
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human GLUL. Recombinant protein control fragment (Product #RP-88686).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2752
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG