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Glycine ethyl ester hydrochloride, 99%, Thermo Scientific Chemicals
Description
Glycine ethyl ester (GEE) is used in conjunction with N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide (EDC) for carboxyl-foot printing studies of proteins. The GEE/EDC protocol effects specific derivatization of glutamate and aspartate carboxyl side chains on intact proteins. This reaction is readily done under aqueous conditions at physiological pH. It is mainly used as a pharmaceutical raw material. Glycine ethyl ester hydrochloride is an important intermediate for preparing chrysanthemic acid or two chlorine chrysanthemic acid and is mainly used in the synthesis of anti-inflammatory drugs, but also can be used for the synthesis of four imidazole acetic acid.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Glycine ethyl ester (GEE) is used in conjunction with N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide (EDC) for carboxyl-foot printing studies of proteins. The GEE/EDC protocol effects specific derivatization of glutamate and aspartate carboxyl side chains on intact proteins. This reaction is readily done under aqueous conditions at physiological pH. It is mainly used as a pharmaceutical raw material. Glycine ethyl ester hydrochloride is an important intermediate for preparing chrysanthemic acid or two chlorine chrysanthemic acid and is mainly used in the synthesis of anti-inflammatory drugs, but also can be used for the synthesis of four imidazole acetic acid.
Solubility
Soluble in water (>1000 mg/ml at 20°C), ethanol, DMSO, and methanol.
Notes
Hygroscopic. Store away from oxidizing agents and water/moisture. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Protect from humidity.
Specifications
| Melting Point | 144°C to 148°C |
| Beilstein | 3594034 |
| Solubility Information | Soluble in water (>1000mg/ml at 20°C),ethanol,DMSO,and methanol. |
| Formula Weight | 139.58 |
| Percent Purity | 99% |
| Quantity | 2500 g |
| Sensitivity | Hygroscopic |
| Chemical Name or Material | Glycine ethyl ester hydrochloride |
Safety and Handling
GHS H Statement
H318
Causes serious eye damage.
GHS P Statement
P280-P305+P351+P338-P310
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.
Continue rinsing.
Immediately call a POISON CENTER or doctor/physician.
Danger
EINECSNumber : 210-787-4
RTECSNumber : MC0525000
TSCA : Yes
Recommended Storage : Ambient temperatures; Store under Nitrogen
RUO – Research Use Only