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Invitrogen™ Glypican 2 Monoclonal Antibody (300736)
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Catalog No. PIMA524012
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100 μg
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Catalog No. Quantity
PIMA524012 100 μg
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Catalog No. PIMA524012 Supplier Invitrogen™ Supplier No. MA524012
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Description

Rat Monoclonal Antibody

In direct ELISAs and Western blots, no cross-reactivity with recombinant human GPC2, 3, 5, or 6 is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

Glypican 2 (GPC2) is a gene located on chromosome 7q22.1, encoding a member of the glypican family of heparan sulfate proteoglycans that are attached to the cell surface via a glycosylphosphatidylinositol (GPI) anchor. Glypicans are involved in the regulation of cell growth, differentiation, and morphogenesis, primarily through their interactions with growth factors and morphogens in the extracellular environment. GPC2 is prominently expressed in the nervous system and plays a significant role in neural development, influencing processes such as neuronal growth and axon guidance. Alterations in GPC2 expression have been linked to neurodevelopmental disorders and certain cancers, such as neuroblastoma, where it can act as an oncofetal antigen. GPC2 is being investigated for its potential as a therapeutic target and biomarker in oncology due to its involvement in tumorigenesis and cancer progression. Research continues to explore its functional mechanisms and its implications in both neurobiology and cancer therapy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Glypican 2
Applications Immunohistochemistry, Western Blot
Classification Monoclonal
Clone 300736
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene GPC2
Gene Accession No. Q8BKV1
Gene Alias 2410016G05Rik; cerebroglycan; cerebroglycan proteoglycan; glypican 2; glypican 2 (cerebroglycan); glypican proteoglycan 2, cerebroglycan proteoglycan; glypican-2; GPC2; HSPG M13; Secreted glypican-2
Gene Symbols GPC2
Host Species Rat
Immunogen Mouse myeloma cell line NS0-derived recombinant mouse Glypican 2 Lys27-Leu554.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 71951
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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