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Invitrogen™ Glypican 2 Polyclonal Antibody
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Catalog No. PIPA548007
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100 μg
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PIPA548007 100 μg
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Catalog No. PIPA548007 Supplier Invitrogen™ Supplier No. PA548007
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Description

Goat Polyclonal Antibody

In direct ELISAs and Western blots, approximately 45% cross-reactivity with recombinant mouse Glypican 2 is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

Glypican 2 (GPC2) is a gene located on chromosome 7q22.1, encoding a member of the glypican family of heparan sulfate proteoglycans that are attached to the cell surface via a glycosylphosphatidylinositol (GPI) anchor. Glypicans are involved in the regulation of cell growth, differentiation, and morphogenesis, primarily through their interactions with growth factors and morphogens in the extracellular environment. GPC2 is prominently expressed in the nervous system and plays a significant role in neural development, influencing processes such as neuronal growth and axon guidance. Alterations in GPC2 expression have been linked to neurodevelopmental disorders and certain cancers, such as neuroblastoma, where it can act as an oncofetal antigen. GPC2 is being investigated for its potential as a therapeutic target and biomarker in oncology due to its involvement in tumorigenesis and cancer progression. Research continues to explore its functional mechanisms and its implications in both neurobiology and cancer therapy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Glypican 2
Applications Immunohistochemistry, Neutralization, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene GPC2
Gene Accession No. Q8N158
Gene Alias 2410016G05Rik; cerebroglycan; cerebroglycan proteoglycan; glypican 2; glypican 2 (cerebroglycan); glypican proteoglycan 2, cerebroglycan proteoglycan; glypican-2; GPC2; HSPG M13; Secreted glypican-2
Gene Symbols GPC2
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant human Glypican 2 Pro18-Ser553.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 221914
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

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