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Glypican 3 Antibody (GPC3/863) - IHC-Prediluted, Novus Biologicals™
SDP

Catalog No. NBP248398 Shop All R&D Systems Products
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NBP248398 7 mL
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Catalog No. NBP248398 Supplier Novus Biologicals Supplier No. NBP248398
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Description

Mouse Monoclonal Antibody

Glypican 3 Monoclonal specifically detects Glypican 3 in Human, Rat samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Glypican 3
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone GPC3/863
Conjugate Unconjugated
Dilution Immunohistochemistry-Paraffin
Formulation 1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Alias DGSX, glypican 3, glypican proteoglycan 3, glypican-3, GTR2-2, heparan sulphate proteoglycan, Intestinal protein OCI-5, MXR7, OCI5, OCI-5, secreted glypican-3, SGB, SGBS, SGBS1SDYS
Gene Symbols GPC3
Host Species Mouse
Immunogen Recombinant full-length human Glypican 3 protein (Uniprot: P51654)
Molecular Weight of Antigen 67 kDa
Purification Method Protein A or G purified
Quantity 7 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2719
Test Specificity Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma.
Target Species Human, Rat
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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