GM-CSFRabbit anti-Human, Polyclonal, Rockland™

Catalog No.	Quantity
50-199-0248	1 mL

Catalog No. 50-199-0248 Supplier Rockland Immunochemicals Supplier No. 109401314

Description

Rabbit Polyclonal Antibody

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. In ELISA and other immunoreactive assays, this antiserum will recognize both native and recombinant human GM-CSF in cell supernatants and certain body fluids. This antibody is useful for neutralization of human GM-CSF in bioassays. For neutralization, it is recommended to incubate the sample with a 1:400 dilution of the antiserum for at least 4 hours before being tested. A control of similarly diluted normal rabbit IgG is recommended.

GM-CSF (Granulocyte-Macrophage colony-stimulating factor) is a 14.6kDa hematopoietic growth factor that exists in glycosylated and non-glycosylated biologically active forms, and stimulates the development of granulocytes, macrophages, early megakaryocytes and eosinophil progenitor cells. The active form of the GM-CSF protein is found extracellularly as a homodimer and the GM-CSF gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q-syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. The ability of recombinant GM-CSF to increase hematopoietic cell recovery has become a focus area in the therapeutic treatment of patients following bone marrow transplantation. Recent studies have investigated GM-CSF in inflammatory and autoimmune diseases such as arthritis, arthritis related interstitial lung disease, nephritis, and psoriasis. In the CNS, GM-CSF depletion or neutralization has been studied in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).

Specifications

• Antigen: GM-CSF
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 85 mg/mL
• Conjugate: Unconjugated
• Formulation: Antibody with no preservative; pH
• Gene: CSF2
• Gene Accession No.: P04141
• Gene Alias: colony stimulating factor 2; colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; Csf2; Csfgm; GMCSF; GM-CSF; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; Granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; MGC151255; MGC151257; MGI-IGM; M-GM-CSF; Molgramostin; put. GM-CSF; Sargramostim
• Gene Symbols: CSF2
• Host Species: Rabbit
• Immunogen: This whole rabbit serum was prepared by repeated immunizations with full length recombinant human GM-CSF.
• Quantity: 1 mL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1437
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid