Invitrogen™ GNA11 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109776

Catalog No. PIPA5109776

Description

Immunogen sequence: ESKALFRTII TYPWFQNSSV ILFLNKKDLL EDKILYSHLV DYFPEFDGPQ RDAQAAREFI LKMFVDLNPD SDKIIYSHFT CATDTENIRF VFAAVKDTIL Q.

Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines and sensory stimuli. To date, over 20 known Gα subunits have been classified into four families, Gα(s), Gα(i/o), Gα(q) and Gα(12), based on structural and functional similarities (1,2). Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Gα with receptors and abolishes ligand-induced IP3 formation (3).

Specifications

• Antigen: GNA11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GNA11
• Gene Alias: Dsk7; E430025L19; FBH; FBH2; FHH2; g alpha-11; G protein subunit alpha 11; GA11; GNA11; Gna-11; G-protein subunit alpha-11; G-protein subunit GL2 alpha; Gq class; GTP-binding protein alpha-subunit; guanine nucleotide binding protein (G protein), alpha 11 (Gq class); guanine nucleotide binding protein alpha 11; guanine nucleotide binding protein, alpha 11; guanine nucleotide regulatory protein G alpha 11; guanine nucleotide-binding protein alpha 11; guanine nucleotide-binding protein alpha 11 subunit; guanine nucleotide-binding protein G(y) subunit alpha; Guanine nucleotide-binding protein subunit alpha-11; HHC2; HYPOC2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14672, 2767, 81662
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.46 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P21278, P29992, Q9JID2
• Gene Symbols: GNA11
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 250-350 of human GNA11 (NP_0020582).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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