Invitrogen™ GNA13 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578338

Catalog No. PIPA578338

Description

Positive Control: 293T, A431, HeLa, HepG2 Predicted Reactivity: Mouse (95%), Rat (95%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). [UniProt].

Specifications

• Antigen: GNA13
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GNA13
• Gene Alias: AU024132; AU043124; G alpha 13; G alpha-13; G protein subunit alpha 13; G13; Galpha 13; Galpha13; Gna13; Gna-13; G-protein subunit alpha-13; guanine nucleotide binding protein (G protein), alpha 13; guanine nucleotide binding protein, alpha 13; guanine nucleotide-binding protein subunit alpha-13
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10672, 14674, 303634
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.29 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P27601, Q14344, Q6Q7Y5
• Gene Symbols: GNA13
• Immunogen: Recombinant protein encompassing a sequence within the center region of human G protein alpha 13. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG