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Invitrogen™ GNA13 Polyclonal Antibody
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Catalog No. PIPA578338
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100 μL
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Catalog No. Quantity
PIPA578338 100 μL
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Catalog No. PIPA578338 Supplier Invitrogen™ Supplier No. PA578338
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Description

Rabbit Polyclonal Antibody

Positive Control: 293T, A431, HeLa, HepG2 Predicted Reactivity: Mouse (95%), Rat (95%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen GNA13
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.29 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene GNA13
Gene Accession No. P27601, Q14344, Q6Q7Y5
Gene Alias AU024132; AU043124; G alpha 13; G alpha-13; G protein subunit alpha 13; G13; Galpha 13; Galpha13; Gna13; Gna-13; G-protein subunit alpha-13; guanine nucleotide binding protein (G protein), alpha 13; guanine nucleotide binding protein, alpha 13; guanine nucleotide-binding protein subunit alpha-13
Gene Symbols GNA13
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human G protein alpha 13. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10672, 14674, 303634
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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