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Invitrogen™ GNA13 Polyclonal Antibody
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Catalog No. PIPA5100664
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100 μL
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PIPA5100664 100 μL
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Catalog No. PIPA5100664 Supplier Invitrogen™ Supplier No. PA5100664
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total GNA13.

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen GNA13
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene GNA13
Gene Accession No. P27601, Q14344, Q6Q7Y5
Gene Alias AU024132; AU043124; G alpha 13; G alpha-13; G protein subunit alpha 13; G13; Galpha 13; Galpha13; Gna13; Gna-13; G-protein subunit alpha-13; guanine nucleotide binding protein (G protein), alpha 13; guanine nucleotide binding protein, alpha 13; guanine nucleotide-binding protein subunit alpha-13
Gene Symbols GNA13
Host Species Rabbit
Immunogen A synthesized peptide derived from human GNA13(Accession Q14344), corresponding to amino acid residues V10-G60.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10672, 14674, 303634
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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