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GNAI3 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA595990
Description
Immunogen sequence: MGCTLSAEDK AAVERSKMID RNLREDGEKA AKEVKLLLLG AGESGKSTIV KQMKIIHEDG YSEDECKQYK VVVYSNTIQS IIAIIRAMGR LKIDFGEAAR; Positive Samples: A-431, Rat kidney; Cellular Location: Cell membrane, Cytoplasm, Lipid-anchor, Membrane, centrosome, cytoskeleton, microtubule organizing center
Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (i. e. adenyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein alpha, beta and gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their alpha subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four distinct classes of Galpha subunits have been identified; these include Gs, Gi, Gq and Galpha 12/13. The Gi class comprises all the known alpha subunits that are susceptible to pertussis toxin modifications, including Galpha i-1, Galpha i-2, Galpha i-3, Galpha o, Galpha t1, Galpha t2, Galpha z and Galpha gust. Of these, the three Galpha i subtypes function to open atrial potassium channels.
Specifications
GNAI3 | |
Polyclonal | |
Unconjugated | |
GNAI3 | |
87U6, AI158965, ARCND1, AW537698, G protein subunit alpha i3, g(i) alpha-3, Galphai3, GIP3A, GNAI3, Gnai-3, guanine nucleotide binding protein (G protein), alpha inhibiting 3, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3, guanine nucleotide binding protein, alpha inhibiting 3, Guanine nucleotide binding, protein, alpha inhibiting polypeptide 3, Guanine nucleotide-binding protein G(i) subunit alpha, guanine nucleotide-binding protein G(k) subunit alpha | |
Rabbit | |
Affinity Chromatography | |
RUO | |
25643, 2773 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
0.64 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3 | |
P08753, P08754 | |
GNAI3 | |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GNAI3 (NP_0064871) | |
100 μL | |
Primary | |
Human, Rat | |
Antibody | |
IgG |
Safety and Handling
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