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GNAI3 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA595990

Catalog No. PIPA595990


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Description

Description

Immunogen sequence: MGCTLSAEDK AAVERSKMID RNLREDGEKA AKEVKLLLLG AGESGKSTIV KQMKIIHEDG YSEDECKQYK VVVYSNTIQS IIAIIRAMGR LKIDFGEAAR; Positive Samples: A-431, Rat kidney; Cellular Location: Cell membrane, Cytoplasm, Lipid-anchor, Membrane, centrosome, cytoskeleton, microtubule organizing center

Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (i. e. adenyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein alpha, beta and gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their alpha subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four distinct classes of Galpha subunits have been identified; these include Gs, Gi, Gq and Galpha 12/13. The Gi class comprises all the known alpha subunits that are susceptible to pertussis toxin modifications, including Galpha i-1, Galpha i-2, Galpha i-3, Galpha o, Galpha t1, Galpha t2, Galpha z and Galpha gust. Of these, the three Galpha i subtypes function to open atrial potassium channels.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

GNAI3
Polyclonal
Unconjugated
GNAI3
87U6, AI158965, ARCND1, AW537698, G protein subunit alpha i3, g(i) alpha-3, Galphai3, GIP3A, GNAI3, Gnai-3, guanine nucleotide binding protein (G protein), alpha inhibiting 3, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3, guanine nucleotide binding protein, alpha inhibiting 3, Guanine nucleotide binding, protein, alpha inhibiting polypeptide 3, Guanine nucleotide-binding protein G(i) subunit alpha, guanine nucleotide-binding protein G(k) subunit alpha
Rabbit
Affinity Chromatography
RUO
25643, 2773
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.64 mg/mL
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
P08753, P08754
GNAI3
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GNAI3 (NP_0064871)
100 μL
Primary
Human, Rat
Antibody
IgG
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