Invitrogen™ GNAS (R201C Mutant) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5119556

Catalog No. PIPA5119556

Description

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5'exons. Some transcripts contain a differentially methylated region (DMR) at their 5'exons, which is commonly found in imprinted genes and correlates with transcript expression. This gene has an antisense transcript. One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Additional transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2015].

Specifications

• Antigen: GNAS (R201C Mutant)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GNAS
• Gene Alias: 5530400H20Rik; A930027G11Rik; alpha stimulating) complex locus; C130027O20Rik; Galphas; GNAS (guanine nucleotide binding protein; Gnas1; Gnasxl; GPSA; Gsa; Gs-alpha; GSP; Nesp; Nesp55; Nespl; Oedsml; Oed-Sml; P1; P2; P3; PHP1A; PHP1B; POH; SCG6
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14683, 2778
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1.52 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: O95467, P63092, P63094, P84996, Q5JWF2, Q6R0H6, Q6R0H7, Q9Z0F1
• Gene Symbols: GNAS
• Immunogen: Carrier-protein conjugated synthetic peptide surrounding mutant R201C of mouse GNAS. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG