Invitrogen™ GNAT3 Polyclonal Antibody

Catalog No.	Quantity
PA550670	100 μL

Catalog No. PA550670 Supplier Invitrogen™ Supplier No. PA550670

Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total GNAT3 protein.

Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.

Specifications

• Antigen: GNAT3
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1.4 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene: GNAT3
• Gene Accession No.: A8MTJ3, P29348, Q3V3I2
• Gene Alias: alpha-gustducin; G protein subunit alpha transducin 3; GDCA; Ggust; Gnat3; gnat-3; Gtn; guanine nucleotide binding protein, alpha transducing 3; guanine nucleotide-binding protein G(t) subunit alpha-3; gustatory G protein; gustducin alpha-3 chain; gustducin, alpha polypeptide
• Gene Symbols: GNAT3
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to residues near the N terminal of human guanine nucleotide binding protein, alpha transducing 3.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 242851, 286924, 346562
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG