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Invitrogen™ GNAT3 Polyclonal Antibody
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Catalog No. PIPA5142320
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100 μg
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PIPA5142320 100 μg
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Catalog No. PIPA5142320 Supplier Invitrogen™ Supplier No. PA5142320
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Description

Goat Polyclonal Antibody

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GNAT3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene GNAT3
Gene Accession No. A8MTJ3
Gene Alias alpha-gustducin; G protein subunit alpha transducin 3; GDCA; Ggust; Gnat3; gnat-3; Gtn; guanine nucleotide binding protein, alpha transducing 3; guanine nucleotide-binding protein G(t) subunit alpha-3; gustatory G protein; gustducin alpha-3 chain; gustducin, alpha polypeptide
Gene Symbols GNAT3
Host Species Goat
Immunogen Peptide with sequence C-KNQFLDLNLKKEDKE.
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 346562
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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