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Tocris Bioscience™ GNE 9278
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Catalog No. 636950
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50 mg
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Catalog No. Quantity
63-695-0 50 mg
63-691-0 10 mg
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Catalog No. 63-695-0 Supplier Tocris Bioscience™ Supplier No. 6369/50
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Description

Positive allosteric modulator of NMDA receptors; acts in transmembrane domain

GNE 9278 is a positive allosteric modulator of NMDA receptors. Potentiates NMDA receptors containing GluN2A, 2B, 2C and 2D subunits (EC50 values are 0.74, 3.07, 0.47 and 0.32 μM in a Ca2+ influx assay, respectively). Binds within the transmembrane domain and displays preference for agonist-bound NMDA receptors. Slows receptor deactivation and enhances the potency of glutamate and glycine .

Specifications

Quantity 50 mg
Molecular Formula C21H27N5O3S
Formula Weight 429.54
Product Type Positive Allosteric Modulator
Purity 98%
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