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Invitrogen™ GNE Polyclonal Antibody
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Catalog No. PIPA552380
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100 μL
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PIPA552380 100 μL
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Catalog No. PIPA552380 Supplier Invitrogen™ Supplier No. PA552380
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DDFDINTRLH TIVRGEDEAA MVESVGLALV KLPDVLNRLK PDIMIVHGDR FDALALATSA ALMNIRILHI EGGEVSGTID DSIRHAITKL AHYHVCCTRS AEQHLISMCE DHDRILLAGC PSYDKLLSAK NKD Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GNE
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene GNE
Gene Accession No. Q9Y223
Gene Alias 2310066H07Rik; bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; DMRV; GLCNE; glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase; GNE; IBM2; ManAc kinase; N-acetylmannosamine kinase; N-acylmannosamine kinase; NM; Uae1; UDP-GlcNAc-2-epimerase; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-N-acetylglucosamine 2-epimerase (hydrolyzing); UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; Uridine diphosphate-N-acetylglucosamine-2-epimerase
Gene Symbols GNE
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human GNE. Recombinant protein control fragment (Product #RP-89764).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10020
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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