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  5. Tocris Bioscience™ GNF 7

Tocris Bioscience™ GNF 7
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Catalog No. 560750
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560710 10 mg
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Catalog No. 560750 Supplier Tocris Bioscience™ Supplier No. 5607/50
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Description

Ras signaling inhibitor; inhibits Ack1 and GCK

GNF 7 is a potent Bcr-Abl inhibitor (IC50 values are 61 and 133 nM for T315I and wild-type Bcr-Abl, respectively), inhibiting a range of clinically relevant Bcr-Abl mutants such as T315I, G250E, E255V, F317L and M351T. GNF 7 is also a Ras signaling inhibitor as well as inhibiting Ack1 and germinal center kinase (GCK). GNF 7 induces cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations, and shows growth inhibitory activity in human colon cancer cells. It prolongs survival in a leukemia cell xenotransplantation model in mice and is orally bioavailable.

Specifications

Chemical Name or Material Ras GTPase Inhibitors
CAS 839706-07-9
Quantity 50 mg
Target Small G Protein Inhibitors
Molecular Formula C28H24F3N7O2
Formula Weight 547.53
Purity >98%
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