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GnRHR (extracellular) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA577448

Catalog No. PIPA577448


Description

Description

Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 μL of deionized water.

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5 region and multiple polyA signals in the 3 region have been identified for this gene.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

GnRHR (extracellular)
Polyclonal
Unconjugated
Gnrhr
Gonadotropin-releasing hormone receptor
Rabbit
Antigen affinity chromatography
RUO
14715, 81668
-20°C
Lyophilized
Immunohistochemistry (Frozen), Western Blot
0.85 mg/mL
PBS with 1% BSA and 0.05% sodium azide; pH 7.4
P30969, Q01776
Gnrhr
Peptide (C)NNASLEQDQNH, corresponding to amino acid residues 3-13 of rat GnRH Receptor
50 μL
Primary
Mouse, Rat
Antibody
IgG
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