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Invitrogen™ GnRHR Monoclonal Antibody (A9E4)
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Catalog No. 01671438
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Quantity:
100 μg
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Catalog No. Quantity
01-671-438 100 μg
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Catalog No. 01-671-438 Supplier Invitrogen™ Supplier No. MA135383
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Description

Mouse Monoclonal Antibody

A9E4 reacts with GnRH receptors in the anterior pituitary. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinising hormone (LH) as well as follicle-stimulating hormone (FSH). The receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular, and intracellular loops, characteristic of G-protein coupled receptors. Some cancers like ovarian and breast cancers sometimes carry GnRH receptors.

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5 region and multiple polyA signals in the 3 region have been identified for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GnRHR
Applications ELISA, Immunohistochemistry (Frozen), Western Blot
Classification Monoclonal
Clone A9E4
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Gnrhr
Gene Accession No. P30968
Gene Alias GH1; GnRH receptor; Gnrhr; gnRH-R; GNRHR1; gonadotropin releasing hormone receptor; gonadotropin releasing hormone receptor type-I; gonadotropin-releasing hormone (type 1) receptor 1; gonadotropin-releasing hormone receptor; GRHR; growth hormone; HH7; HHG; hypergonadotropic hypogonadism; LCGR; leutinizing hormone releasing horomone receptor; leutinizing-releasing hormone receptor; LGR2; LH/CGR; LH/CG-R; LHCGR; LHR; Lh-rh receptor; Lhrhr; LRHR; LSH-R; luliberin receptor; Luteinizing hormone receptor; luteinizing hormone/choriogonadotropin receptor; lutropin/choriogonadotropin receptor; lutropin-choriogonadotropic hormone receptor; type I GnRH receptor; Type I GNRHR1; ULG5
Gene Symbols Gnrhr
Host Species Mouse
Immunogen BSA-conjugated peptide corresponding to amino acids 1-29 of human GnRH receptor extracellular domain.
Purification Method Purified
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2798
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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