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Invitrogen™ GnRHR Monoclonal Antibody (A9E4)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA135383
Description
A9E4 reacts with GnRH receptors in the anterior pituitary. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinising hormone (LH) as well as follicle-stimulating hormone (FSH). The receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular, and intracellular loops, characteristic of G-protein coupled receptors. Some cancers like ovarian and breast cancers sometimes carry GnRH receptors.
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5 region and multiple polyA signals in the 3 region have been identified for this gene.
Specifications
GnRHR | |
Monoclonal | |
0.1 mg/mL | |
PBS with 0.02% sodium azide | |
P30968 | |
Gnrhr | |
BSA-conjugated peptide corresponding to amino acids 1-29 of human GnRH receptor extracellular domain. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 κ |
ELISA, Immunohistochemistry (Frozen), Western Blot | |
A9E4 | |
Unconjugated | |
Gnrhr | |
GH1; GnRH receptor; Gnrhr; gnRH-R; GNRHR1; gonadotropin releasing hormone receptor; gonadotropin releasing hormone receptor type-I; gonadotropin-releasing hormone (type 1) receptor 1; gonadotropin-releasing hormone receptor; GRHR; growth hormone; HH7; HHG; hypergonadotropic hypogonadism; LCGR; leutinizing hormone releasing horomone receptor; leutinizing-releasing hormone receptor; LGR2; LH/CGR; LH/CG-R; LHCGR; LHR; Lh-rh receptor; Lhrhr; LRHR; LSH-R; luliberin receptor; Luteinizing hormone receptor; luteinizing hormone/choriogonadotropin receptor; lutropin/choriogonadotropin receptor; lutropin-choriogonadotropic hormone receptor; type I GnRH receptor; Type I GNRHR1; ULG5 | |
Mouse | |
Purified | |
RUO | |
2798 | |
4°C | |
Liquid |
Safety and Handling
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