Invitrogen™ GnRHR Monoclonal Antibody (A9E4)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA135383

Catalog No. 01-671-438

Description

A9E4 reacts with GnRH receptors in the anterior pituitary. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinising hormone (LH) as well as follicle-stimulating hormone (FSH). The receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular, and intracellular loops, characteristic of G-protein coupled receptors. Some cancers like ovarian and breast cancers sometimes carry GnRH receptors.

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5 region and multiple polyA signals in the 3 region have been identified for this gene.

Specifications

• Antigen: GnRHR
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P30968
• Gene Symbols: Gnrhr
• Immunogen: BSA-conjugated peptide corresponding to amino acids 1-29 of human GnRH receptor extracellular domain.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: ELISA, Immunohistochemistry (Frozen), Western Blot
• Clone: A9E4
• Conjugate: Unconjugated
• Gene: Gnrhr
• Gene Alias: GH1; GnRH receptor; Gnrhr; gnRH-R; GNRHR1; gonadotropin releasing hormone receptor; gonadotropin releasing hormone receptor type-I; gonadotropin-releasing hormone (type 1) receptor 1; gonadotropin-releasing hormone receptor; GRHR; growth hormone; HH7; HHG; hypergonadotropic hypogonadism; LCGR; leutinizing hormone releasing horomone receptor; leutinizing-releasing hormone receptor; LGR2; LH/CGR; LH/CG-R; LHCGR; LHR; Lh-rh receptor; Lhrhr; LRHR; LSH-R; luliberin receptor; Luteinizing hormone receptor; luteinizing hormone/choriogonadotropin receptor; lutropin/choriogonadotropin receptor; lutropin-choriogonadotropic hormone receptor; type I GnRH receptor; Type I GNRHR1; ULG5
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 2798
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov