ABCC5, Goat, Polyclonal Antibody, Abnova™
Goat polyclonal antibody raised against synthetic peptide of ABCC5.
Supplier: Abnova Corporation PAB7484
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeqSequence: KDIDIGKEYIIP-C
|ELISA (1:32000) Western Blot (0.5-1.5 ug/mL) The optimal working dilution should be determined by the end user.|
|Antigen affinity purification|
|ELISA, Western Blot|
|Goat polyclonal antibody raised against synthetic peptide of ABCC5.|
|In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)|
|A synthetic peptide corresponding to human ABCC5.|
|This antibody is expected to recognize both reported isoforms (NP_005679.2, NP_001018881.1).|
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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For Research Use Only