ACO1, Goat, Polyclonal Antibody, Abnova™

Goat polyclonal antibody raised against synthetic peptide of ACO1.

Supplier:  Abnova Corporation PAB18708

Catalog No. 89-120-263

Description

Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes. [provided by RefSeq]

Sequence: C-QVDFNRRADSLQKNQ

Specifications

• Antigen: ACO1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:8000) Western Blot (0.1-0.3 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: ACO1
• Gene Alias: ACONS/IREB1/IREBP/IREBP1/IRP1
• Host Species: Goat
• Purification Method: Antigen affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 48
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: ELISA, Western Blot
• Concentration: 0.5 mg/mL
• Description: Goat polyclonal antibody raised against synthetic peptide of ACO1.
• Formulation: In Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
• Gene Accession No.: NP_002188.1
• Gene Symbols: ACO1
• Immunogen: A synthetic peptide corresponding to amino acids at internal region of human ACO1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid

For Research Use Only