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AVPR2, Goat, Polyclonal Antibody, Abnova™

Goat polyclonal antibody raised against synthetic peptide of AVPR2.

Supplier:  Abnova Corporation PAB7492

Catalog No. 89-133-303


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Description

Description

This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq

Sequence: CARGRTPPSLGPQDE
Specifications

Specifications

AVPR2
Polyclonal
Unconjugated
ELISA (1:64000) The optimal working dilution should be determined by the end user.
AVPR2
ADHR/DI1/DIR/DIR3/MGC126533/MGC138386/NDI/V2R
Goat
Antigen affinity purification
RUO
554
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
ELISA
0.5 mg/mL
Goat polyclonal antibody raised against synthetic peptide of AVPR2.
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
NP_000045.1
AVPR2
A synthetic peptide corresponding to human AVPR2.
100 μg
Primary
Human
Liquid
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