COMT Goat anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-132-934	100 μg

Catalog No. 89-132-934 Supplier Abnova Corporation Supplier No. PAB7078

Description

Goat polyclonal antibody raised against synthetic peptide of COMT.

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq

Sequence: C-QDIIPQLKKKYDVD

Specifications

• Antigen: COMT
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Description: Goat polyclonal antibody raised against synthetic peptide of COMT.
• Dilution: ELISA (1:64000) Sandwich ELISA (0.5-2 ug/mL) Western Blot (0.03-0.1 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
• Gene: COMT
• Gene Accession No.: NP_000745.1;NP_009294.1
• Gene Symbols: COMT
• Host Species: Goat
• Immunogen: A synthetic peptide corresponding to internal region of human COMT.
• Purification Method: Antigen affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1312
• Test Specificity: This antibody is expected to recognize both reported isoforms (NP_000745.1 and NP_009294.1).
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only