CYP3A4, Goat, Polyclonal Antibody, Abnova™
Goat polyclonal antibody raised against synthetic peptide of CYP3A4.
Supplier: Abnova Corporation PAB7000
This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeqSequence: C-KESRLEDTQKHR
|ELISA (1:8000) The optimal working dilution should be determined by the end user.|
|Antigen affinity purification|
|Goat polyclonal antibody raised against synthetic peptide of CYP3A4.|
|In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)|
|A synthetic peptide corresponding to human CYP3A4.|
|This antibody is not expected to cross-react with 3A5, 3A7 ot 3A43.|
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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