DCTN1, Goat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-132-273	100 μg

Catalog No. 89-132-273 Supplier Abnova Corporation Supplier No. PAB6249

Description

Goat polyclonal antibody raised against synthetic peptide of DCTN1.

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150kDa. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq

Sequence: C-QEQLHQLHSRLIS

Specifications

• Antigen: DCTN1
• Applications: ELISA, Immunohistochemistry (PFA fixed), Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Description: Goat polyclonal antibody raised against synthetic peptide of DCTN1.
• Dilution: ELISA (1:128000) Western Blot (0.5-2 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-4 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
• Gene: DCTN1
• Gene Accession No.: NP_004073.2;NP_075408.1;NP_001128512.1;NP_001128513.1
• Gene Alias: DAP-150/DP-150/HMN7B/P135
• Gene Symbols: DCTN1
• Host Species: Goat
• Immunogen: A synthetic peptide corresponding to C-terminus of human DCTN1.
• Purification Method: Antigen affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1639
• Test Specificity: This antibody is expected to recognize all reported isoforms (NP_004073.2; NP_075408.1; NP_001128512.1; NP_001128513.1).
• Target Species: Human, Mouse
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only