DCTN1, Goat, Polyclonal Antibody, Abnova™
Goat polyclonal antibody raised against synthetic peptide of DCTN1.
Supplier: Abnova Corporation PAB6249
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150kDa. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeqSequence: C-QEQLHQLHSRLIS
|ELISA (1:128000) Western Blot (0.5-2 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-4 ug/mL) The optimal working dilution should be determined by the end user.|
|Antigen affinity purification|
|ELISA, Immunohistochemistry (PFA fixed), Western Blot|
|Goat polyclonal antibody raised against synthetic peptide of DCTN1.|
|In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)|
|A synthetic peptide corresponding to C-terminus of human DCTN1.|
|This antibody is expected to recognize all reported isoforms (NP_004073.2; NP_075408.1; NP_001128512.1; NP_001128513.1).|
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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