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DUSP1, Goat, Polyclonal Antibody, Abnova™

Catalog No. 89132107 Shop All Abnova Corporation Products
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100 μg
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89-132-107 100 μg
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Catalog No. 89-132-107 Supplier Abnova Corporation Supplier No. PAB6062
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Description

Goat polyclonal antibody raised against synthetic peptide of DUSP1.

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the nonreceptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq

Sequence: SYLQSPITTSPSC

Specifications

Antigen DUSP1
Applications ELISA, Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Description Goat polyclonal antibody raised against synthetic peptide of DUSP1.
Dilution ELISA (1:32000) Western blot (0.3-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-5 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Gene DUSP1
Gene Accession No. NP_004408.1
Gene Alias CL100/HVH1/MKP-1/MKP1/PTPN10
Gene Symbols DUSP1
Host Species Goat
Immunogen A synthetic peptide corresponding to C-terminus of human DUSP1.
Purification Method Antigen affinity purification
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1843
Target Species Human, Mouse, Rat
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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