DYRK1A, Goat, Polyclonal Antibody, Abnova™

Goat polyclonal antibody raised against synthetic peptide of DYRK1A.

Supplier:  Abnova Corporation PAB27523

Catalog No. 89-129-032

Description

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq

Sequence: PHSHQYSDRRQPN

Specifications

• Antigen: DYRK1A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:64000) Western Blot (0.5-2ug/ml) The optimal working dilution should be determined by the end user.
• Gene: DYRK1A
• Gene Alias: DYRK/DYRK1/HP86/MNB/MNBH
• Host Species: Goat
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 1859
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Description: Goat polyclonal antibody raised against synthetic peptide of DYRK1A.
• Formulation: In Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
• Gene Accession No.: NP_001387.2;NP_569120.1;NP_567824.1;NP_569122.1
• Gene Symbols: DYRK1A
• Immunogen: A synthetic peptide corresponding to N-terminus of human DYRK1A.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Canine, Chicken, Human, Mouse, Porcine, Rat

For Research Use Only