ENC1, Goat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-129-063	100 μg

Catalog No. 89-129-063 Supplier Abnova Corporation Supplier No. PAB27552

Description

Goat polyclonal antibody raised against synthetic peptide of ENC1.

DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) [PubMed 9305847] used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) [PubMed 9305847] termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.[supplied by OMIM

Sequence: TSVSHDKLPKVQC

Specifications

• Antigen: ENC1
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Description: Goat polyclonal antibody raised against synthetic peptide of ENC1.
• Dilution: ELISA (1:128000) Western Blot (1-3ug/ml) The optimal working dilution should be determined by the end user.
• Formulation: In Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
• Gene: ENC1
• Gene Accession No.: NP_003624.1;NP_001243505.1
• Gene Alias: CCL28/ENC-1/FLJ39259/KLHL35/KLHL37/NRPB/PIG10/TP53I10
• Gene Symbols: ENC1
• Host Species: Goat
• Immunogen: A synthetic peptide corresponding to internal region of human ENC1.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8507
• Target Species: Canine, Chicken, Human, Mouse, Pig, Rat
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only