FXYD5, Goat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-132-173	100 μg

Catalog No. 89-132-173 Supplier Abnova Corporation Supplier No. PAB6132

Description

Goat polyclonal antibody raised against synthetic peptide of FXYD5.

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D.

Sequence: GKCRQLSRLCRNHCR

Specifications

• Antigen: FXYD5
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Description: Goat polyclonal antibody raised against synthetic peptide of FXYD5.
• Dilution: ELISA (1:8000) Western Blot (0.5-1.5 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
• Gene: FXYD5
• Gene Accession No.: NP_054883.1;NP_6590.03.1
• Gene Alias: HSPC113/IWU-1/IWU1/KCT1/OIT2/PRO6241/RIC/dysad
• Gene Symbols: FXYD5
• Host Species: Goat
• Immunogen: A synthetic peptide corresponding to human FXYD5.
• Purification Method: Antigen affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 53827
• Test Specificity: NP_054883.1 and NP_6590.03.1 are variants that represent the same protein.
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only