GRM2, Goat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-120-557	100 μg

Catalog No. 89-120-557 Supplier Abnova Corporation Supplier No. PAB19004

Description

Goat polyclonal antibody raised against synthetic peptide of GRM2.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Sequence: C-KETAPERREV

Specifications

• Antigen: GRM2
• Applications: ELISA, Immunohistochemistry (PFA fixed), Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Description: Goat polyclonal antibody raised against synthetic peptide of GRM2.
• Dilution: ELISA (1:16000) Western Blot (1-3 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-5 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In 0.5mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
• Gene: GRM2
• Gene Accession No.: NP_000830.2;NP_001123535.1
• Gene Alias: GLUR2/GPRC1B/MGLUR2/mGlu2
• Gene Symbols: GRM2
• Host Species: Goat
• Immunogen: A synthetic peptide corresponding to internal region of human GRM2.
• Purification Method: Antigen affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2912
• Test Specificity: This antibody is expected to recognize both isoforms (NP_000830.2; NP_001123535.1).
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only