GRM7, Goat, Polyclonal Antibody, Abnova™

Goat polyclonal antibody raised against synthetic peptide of GRM7.

Supplier:  Abnova Corporation PAB12813

Catalog No. 89-116-106

Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Sequence: NCKLTISGSKKEDT

Specifications

• Antigen: GRM7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:32000) Western blot (0.5-2 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: GRM7
• Gene Alias: FLJ40498/GLUR7/GPRC1G/MGLUR7/mGlu7
• Host Species: Goat
• Purification Method: Antigen affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 2917
• Target Species: Human
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.5 mg/mL
• Description: Goat polyclonal antibody raised against synthetic peptide of GRM7.
• Formulation: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
• Gene Accession No.: NP_000835.1;NP_870989.1
• Gene Symbols: GRM7
• Immunogen: A synthetic peptide corresponding to amino acids at internal region of human GRM7.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: This antibody is expected to recognize both reported isoforms (NP_000835.1; NP_870989.1). 100 KDa band observed in human Brain (Cerebellum) and in Mouse and Rat Brain lysates (calculated MW of 102 KDa according to NP_000835.1).
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only