GRN, Goat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-116-105	100 μg

Catalog No. 89-116-105 Supplier Abnova Corporation Supplier No. PAB12812

Description

Goat polyclonal antibody raised against synthetic peptide of GRN.

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq

Sequence: QSKCLSKENATTD

Specifications

• Antigen: GRN
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Description: Goat polyclonal antibody raised against synthetic peptide of GRN.
• Dilution: ELISA (1:8000) Western blot (1-3 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
• Gene: GRN
• Gene Accession No.: NP_002078.1
• Gene Alias: GEP/GP88/PCDGF/PEPI/PGRN
• Gene Symbols: GRN
• Host Species: Goat
• Immunogen: A synthetic peptide corresponding to amino acids at internal region of human GRN.
• Purification Method: Antigen affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2896
• Test Specificity: 60 KDa band observed in lysates of A549 and HeLa (calculated MW of 63.5 KDa according to NP_002078.1).
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only