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Description
CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.[supplied by OMIM
Specifications
Specifications
| Antigen | HAVCR2 |
| Applications | ELISA, Western Blot |
| Classification | Polyclonal |
| Concentration | 0.5 mg/mL |
| Conjugate | Unconjugated |
| Description | Goat polyclonal antibody raised against synthetic peptide of HAVCR2. |
| Dilution | ELISA (1:32000) Western Blot (0.3-1 ug/mL) The optimal working dilution should be determined by the end user. |
| Formulation | In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide) |
| Gene | HAVCR2 |
| Gene Alias | FLJ14428/KIM-3/TIM3/TIMD3/Tim-3 |
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