MDM2, Goat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-132-783	100 μg

Catalog No. 89-132-783 Supplier Abnova Corporation Supplier No. PAB6902

Description

Goat polyclonal antibody raised against synthetic peptide of MDM2.

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq

Sequence: C-DELSGERQRKRHKSD

Specifications

• Antigen: MDM2
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Description: Goat polyclonal antibody raised against synthetic peptide of MDM2.
• Dilution: ELISA (1:64000) Western Blot (0.3-1 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
• Gene: MDM2
• Gene Alias: HDMX/MGC71221/hdm2
• Gene Symbols: MDM2
• Host Species: Goat
• Immunogen: A synthetic peptide corresponding to human MDM2.
• Purification Method: Antigen affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4193
• Test Specificity: This antibody is expected to recognize isoform MDM2 (NP_002383.2) only.
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only