NCF4, Goat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-133-138	100 μg

Catalog No. 89-133-138 Supplier Abnova Corporation Supplier No. PAB7315

Description

Goat polyclonal antibody raised against synthetic peptide of NCF4.

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq

Sequence: C-KDFPEEDDPTN

Specifications

• Antigen: NCF4
• Applications: ELISA, Immunohistochemistry (PFA fixed), Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Description: Goat polyclonal antibody raised against synthetic peptide of NCF4.
• Dilution: ELISA (1:32000) Western blot (0.3-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-4 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
• Gene: NCF4
• Gene Alias: MGC3810/NCF/P40PHOX/SH3PXD4
• Gene Symbols: NCF4
• Host Species: Goat
• Immunogen: A synthetic peptide corresponding to human NCF4.
• Purification Method: Antigen affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4689
• Test Specificity: This antibody is expected to recognize both reported isoforms (NP_000622.2 and NP_0.38202.1).
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only