NOTCH3, Goat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-132-799	100 μg

Catalog No. 89-132-799 Supplier Abnova Corporation Supplier No. PAB6918

Description

Goat polyclonal antibody raised against synthetic peptide of NOTCH3.

This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq

Sequence: C-QLGPQPEVTPKRQ

Specifications

• Antigen: NOTCH3
• Applications: ELISA, Immunohistochemistry (PFA fixed)
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Description: Goat polyclonal antibody raised against synthetic peptide of NOTCH3.
• Dilution: ELISA (1:32000) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-6 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
• Gene: NOTCH3
• Gene Alias: CADASIL/CASIL
• Gene Symbols: NOTCH3
• Host Species: Goat
• Immunogen: A synthetic peptide corresponding to C-terminus of human NOTCH3.
• Purification Method: Antigen affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4854
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only