PPARD, Goat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-132-592	100 μg

Catalog No. 89-132-592 Supplier Abnova Corporation Supplier No. PAB6679

Description

Goat polyclonal antibody raised against synthetic peptide of PPARD.

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. [provided by RefSeq

Sequence: CHPLLQEIYKDMY

Specifications

• Antigen: PPARD
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Description: Goat polyclonal antibody raised against synthetic peptide of PPARD.
• Dilution: ELISA (1:32000) Western Blot (1-3 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
• Gene: PPARD
• Gene Alias: FAAR/MGC3931/NR1C2/NUC1/NUCI/NUCII/PPAR-beta/PPARB
• Gene Symbols: PPARD
• Host Species: Goat
• Immunogen: A synthetic peptide corresponding to C-terminus of human PPARD.
• Purification Method: Antigen affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5467
• Test Specificity: This antibody is expected to recognize isoform 1 (NP_006229) of PPAR delta, but not isoform 2, a shorter protein (NP_80.3184) with a different C-terminus.
• Target Species: Human, Rat
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only