PSMB8, Goat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-117-040	100 μg

Catalog No. 89-117-040 Supplier Abnova Corporation Supplier No. PAB14398

Description

Goat polyclonal antibody raised against synthetic peptide of PSMB8.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 nonidentical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a nonlysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq

Sequence: C-DVSDLLHQYREANQ

Specifications

• Antigen: PSMB8
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Description: Goat polyclonal antibody raised against synthetic peptide of PSMB8.
• Dilution: ELISA (1:8000) Western Blot (0.01-0.03 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
• Gene: PSMB8
• Gene Alias: D6S216/D6S216E/LMP7/MGC1491/PSMB5i/RING10/beta5i
• Gene Symbols: PSMB8
• Host Species: Goat
• Immunogen: A synthetic peptide corresponding to human PSMB8.
• Purification Method: Antigen affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5696
• Test Specificity: Approx 22 KDa band observed in human liver, lung and lymph node lysates (calculated MW of 29.8 KDa according to precursor NP_004150.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Schwarz et al, J Immunol. 2000 Jul 15;165(2):768-78. PMID: 10878350.
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only