PSME1, Goat, Polyclonal Antibody, Abnova™

Goat polyclonal antibody raised against synthetic peptide of PSME1.

Supplier:  Abnova Corporation PAB7267

Catalog No. 89-133-096

Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 nonidentical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a nonlysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified. [provided by RefSeq

Sequence: C-KNFEKLKKPRGETK

Specifications

• Antigen: PSME1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:64000) Western Blot (0.3-1 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: PSME1
• Gene Symbols: PSME1
• Immunogen: A synthetic peptide corresponding to human PSME1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: This antibody is expected to recognize isoform 1 (NP_006254.1).
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: ELISA, Western Blot
• Concentration: 0.5 mg/mL
• Description: Goat polyclonal antibody raised against synthetic peptide of PSME1.
• Formulation: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
• Gene Alias: IFI5111/MGC8628/PA28A/PA28alpha/REGalpha
• Host Species: Goat
• Purification Method: Antigen affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 5720
• Target Species: Human
• Form: Liquid

For Research Use Only