PTBP1, Goat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-132-433	100 μg

Catalog No. 89-132-433 Supplier Abnova Corporation Supplier No. PAB6476

Description

Goat polyclonal antibody raised against synthetic peptide of PTBP1.

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq

Sequence: DGIVPDIAVGTKR-C

Specifications

• Antigen: PTBP1
• Applications: ELISA, Immunohistochemistry (PFA fixed), Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Description: Goat polyclonal antibody raised against synthetic peptide of PTBP1.
• Dilution: ELISA (1:8000) Western blot (1-3 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5-10 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
• Gene: PTBP1
• Gene Alias: HNRNP-I/HNRNPI/HNRPI/MGC10830/MGC8461/PTB/PTB-1/PTB-T/PTB2/PTB3/PTB4/pPTB
• Gene Symbols: PTBP1
• Host Species: Goat
• Immunogen: A synthetic peptide corresponding to human PTBP1.
• Purification Method: Antigen affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5725
• Test Specificity: This antibody is expected to recognize all 4 reported isoforms (represented by NP_002810.1, NP_114367.1, NP_114368.1, NP_787041.1).
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only