PYCARD, Goat, Polyclonal Antibody, Abnova™

Goat polyclonal antibody raised against synthetic peptide of PYCARD.

Supplier:  Abnova Corporation PAB6098

Catalog No. 89-132-142

Description

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Sequence: C-RESQSYLVEDLERS

Specifications

• Antigen: PYCARD
• Classification: Polyclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:32000) Western Blot (1-3 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-4 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: PYCARD
• Gene Symbols: PYCARD
• Immunogen: A synthetic peptide corresponding to C-terminus of human PYCARD.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: This antibody is expected to recognize all three reported human isoforms according to NP_037390.2, NP_660183.1 and NP_660184.1.
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: ELISA, Immunohistochemistry (PFA fixed), Western Blot
• Concentration: 0.5 mg/mL
• Description: Goat polyclonal antibody raised against synthetic peptide of PYCARD.
• Formulation: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
• Gene Alias: ASC/CARD5/MGC10332/TMS/TMS-1/TMS1
• Host Species: Goat
• Purification Method: Antigen affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 29108
• Target Species: Human
• Form: Liquid

For Research Use Only