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RARA, Goat, Polyclonal Antibody, Abnova™

Catalog No. 89132660 Shop All Abnova Corporation Products
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89-132-660 100 μg
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Catalog No. 89-132-660 Supplier Abnova Corporation Supplier No. PAB6755
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Description

Goat polyclonal antibody raised against synthetic peptide of RARA.

Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR; see MIM 180245), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 (MIM 600849), SMRT (NCOR2; MIM 600848), and histone deacetylase (see MIM 601241). When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases (see MIM 603053), and the basic transcription machinery. Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (MIM 102578) (Vitoux et al., 2007 [PubMed 17468032]).[supplied by OMIM

Sequence: C-SPSLSPSSHRSSPATQSP

Specifications

Antigen RARA
Applications ELISA, Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Description Goat polyclonal antibody raised against synthetic peptide of RARA.
Dilution ELISA (1:8000) Western blot (1-3 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-6 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Gene RARA
Gene Alias NR1B1/RAR
Gene Symbols RARA
Host Species Goat
Immunogen A synthetic peptide corresponding to human RARA.
Purification Method Antigen affinity purification
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5914
Test Specificity NP_000955.1 (isfa) and NP_001028775.1(alpha) represent identical proteins. This antibody is expected to recognize all three reported isoforms (NP_000955.1; NP_001019980.1; NP_001028775.1). Please note the epitope is from the mouse/rat sequence. Human sequence is SPSLSPSSNRSSPATHSP and thus highly similar.
Target Species Human
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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