SIGLEC12, Goat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-132-336	100 μg

Catalog No. 89-132-336 Supplier Abnova Corporation Supplier No. PAB6335

Description

Goat polyclonal antibody raised against synthetic peptide of SIGLEC12.

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq

Sequence: C-EAIGYEYSEINIPK

Specifications

• Antigen: SIGLEC12
• Applications: ELISA
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Description: Goat polyclonal antibody raised against synthetic peptide of SIGLEC12.
• Dilution: ELISA (1:128000) The optimal working dilution should be determined by the end user.
• Formulation: In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
• Gene: SIGLEC12
• Gene Alias: FLJ38600/S2V/SIGLECL1/SLG/Siglec-12/Siglec-L1/Siglec-XII
• Gene Symbols: SIGLEC12
• Host Species: Goat
• Immunogen: A synthetic peptide corresponding to human SIGLEC12.
• Purification Method: Antigen affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 89858
• Test Specificity: This antibody is expected to recognize both human isoforms of this protein (NP_201586; NP_443729).
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only