TBP (isoform 1), Goat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-126-319	100 μg

Catalog No. 89-126-319 Supplier Abnova Corporation Supplier No. PAB24603

Description

Goat polyclonal antibody raised against synthetic peptide of TBP (isoform 1).

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. [provided by RefSeq

Sequence: DQNNSLPPYAQC

Specifications

• Antigen: TBP (isoform1)
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Description: Goat polyclonal antibody raised against synthetic peptide of TBP (isoform1).
• Dilution: ELISA (1:64000) Western Blot (0.3-1 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In 0.5mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
• Gene: TBP
• Gene Alias: GTF2D/GTF2D1/MGC117320/MGC126054/MGC126055/SCA17/TFIID
• Gene Symbols: TBP
• Host Species: Goat
• Immunogen: A synthetic peptide corresponding to N-terminus of human TBP (isoform1).
• Purification Method: Antigen affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6908
• Test Specificity: This antibody is expected to recognize reported isoform 1(NP_003185.1) only.
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only