TERT, Goat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-126-297	100 μg

Catalog No. 89-126-297 Supplier Abnova Corporation Supplier No. PAB24580

Description

Goat polyclonal antibody raised against synthetic peptide of TERT.

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq

Sequence: C-QLRELSEAEVRQHRE

Specifications

• Antigen: TERT
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Goat polyclonal antibody raised against synthetic peptide of TERT.
• Dilution: ELISA (1:32000) Western Blot (0.3-1 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In 0.5mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
• Gene: TERT
• Gene Alias: EST2/TCS1/TP2/TRT/hEST2
• Gene Symbols: TERT
• Host Species: Goat
• Immunogen: A synthetic peptide corresponding to amino acids 597-611 at internal region of human TERT.
• Purification Method: Antigen affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7015
• Test Specificity: This antibody is expected to recognize both reported isoforms (NP_937983.2; (NP_001180305.1).
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only