UMOD Goat anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-129-052	100 μg

Catalog No. 89-129-052 Supplier Abnova Corporation Supplier No. PAB27542

Description

Goat polyclonal antibody raised against synthetic peptide of UMOD.

This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq

Sequence: DRCPHTRDSTIQ

Specifications

• Antigen: UMOD
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Description: Goat polyclonal antibody raised against synthetic peptide of UMOD.
• Dilution: ELISA (1:128000) Western Blot (0.3-1ug/ml) The optimal working dilution should be determined by the end user.
• Formulation: In Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
• Gene: UMOD
• Gene Alias: ADMCKD2/FJHN/HNFJ/MCKD2/THGP/THP
• Gene Symbols: UMOD
• Host Species: Goat
• Immunogen: A synthetic peptide corresponding to amino acids 525-536 at internal region of human UMOD.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7369
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only