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Invitrogen™ GOLPH3 Monoclonal Antibody (905CT9.1.1)
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Catalog No. PIMA537626
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400 μL
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Catalog No. Quantity
PIMA537626 400 μL
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Catalog No. PIMA537626 Supplier Invitrogen™ Supplier No. MA537626
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Description

Mouse Monoclonal Antibody

GOLPH3 Monoclonal Antibody for Western Blot

GOLPH3 was initially identified as a peripheral membrane protein localized to the trans-Golgi network, but others reported it to be primarily a mitochondrial protein that regulated the mitochondrial mass through the regulation of the mitochondria-specific phospholipid cardiolipin. GOLPH3 has since been implicated in the target of rapamycin (TOR) signaling pathway. Its overexpression in transfected cells led to and increase in anchorage-independent growth and cell proliferation in vitro. Furthermore, GOLPH3-transfected cells enhanced S6 Kinase activity in response to growth factor stimulation by EGF. Simultaneously, AKT phosphorylation increased in these cells, while these events were abrogated in GOLPH3 siRNA treated cells compared to control cells, indicating the GOLPH3 can enhance signaling through TOR-associated complexes. These results suggest that GOLPH3 is a bona fide oncogene and may be a useful target for therapeutic strategies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GOLPH3
Applications Western Blot
Classification Monoclonal
Clone 905CT9.1.1
Concentration 0.45 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene Golph3
Gene Accession No. Q9H4A6
Gene Alias 4733401N08Rik; 5730410D03Rik; AW413496; coat protein GPP34; coat-protein; Gmx33; golgi peripheral membrane protein 1, 34 kDa; Golgi phosphoprotein 3; golgi phosphoprotein 3 (coat-protein); golgi protein; golgi-associated protein; GOLPH3; GOPP1; GPP34; MIDAS; Mitochondrial DNA absence factor; trans-Golgi protein GMx33; Vps74
Gene Symbols Golph3
Host Species Mouse
Immunogen purified His-tagged GOLPH3 protein.
Purification Method Protein G
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64083
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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